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Staff List
Dr Cynthia Coleman
PhD
Contact Details
Lecturer Above the Bar in Cellular Manufacturing & Therapy
Regenerative Medicine Insitute
Biosciences 1FS, Dangan Campus
NUI Galway
H91 W2TY
T: (0)91 49 5852
E: cynthia.coleman@nuigalway.ie
Regenerative Medicine Insitute
Biosciences 1FS, Dangan Campus
NUI Galway
H91 W2TY
T: (0)91 49 5852
E: cynthia.coleman@nuigalway.ie
Biography
Research Interests
Research Projects
| Project | Start Date | End Date | |
|---|---|---|---|
| Identifying the Aetiology of Diabetic Progenitor Cell Dysfunction in Osteoporosis | 01-NOV-16 | 31-OCT-18 | |
| Investigating Cell Ingrowth into a Natural Bone Replacement Scaffold | 01-NOV-16 | 31-OCT-17 | |
| PURESTEM: Utilization of the Mesenchymal Stem Cell Receptome for Rational Development of Uniform, Serum-free Conditions and Tools for Cell Characterization | 01-NOV-08 | 01-NOV-10 | |
| REDDSTAR: Repair of Diabetic Damage by Stromal Cell Administration | 01-NOV-12 | 01-NOV-15 |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2021) | 'The Influence of Lactation and its Duration on Bone Mineral Density in Pregnancy and Postpartum: A Systematic Review with Meta-Analysis'
I. Oboh, C.M. Coleman, A. Cremona (2021) 'The Influence of Lactation and its Duration on Bone Mineral Density in Pregnancy and Postpartum: A Systematic Review with Meta-Analysis'. Clinical Nutrition, :121-132 [DOI] [Details] |
|
| (2020) | 'Administration of Human Non-Diabetic Mesenchymal Stromal Cells to a Murine Model of Diabetic Fracture Repair: A Pilot Study'
Watson L;Chen XZ;Ryan AE;Fleming Á;Carbin A;O'Flynn L;Loftus PG;Horan E;Connolly D;McDonnell P;McNamara LM;O'Brien T;Coleman CM; (2020) 'Administration of Human Non-Diabetic Mesenchymal Stromal Cells to a Murine Model of Diabetic Fracture Repair: A Pilot Study'. Cells, 9 (6):1-20 [DOI] [Details] |
|
| (2020) | 'Impact of type 2 diabetes mellitus on human bone marrow stromal cell number and phenotypic characteristics'
F. Cassidy, C. Shortiss, C. Murphy, S. Kearnes, W. Curtin, C. DeBuitleir, T. O’Brien, C.M. Coleman (2020) 'Impact of type 2 diabetes mellitus on human bone marrow stromal cell number and phenotypic characteristics'. International Journal Of Molecular Sciences, 21 (7):2476-2496 [DOI] [Details] |
|
| (2020) | 'Knowledge and Perceptions and Concerns of Diabetes-Associated Complications Among Individuals Living with Type 1 and Type 2 Diabetes Mellitus'
C. Sanz-Nogues, M. Mustafa, H. Burke, T. O’Brien, C.M. Coleman (2020) 'Knowledge and Perceptions and Concerns of Diabetes-Associated Complications Among Individuals Living with Type 1 and Type 2 Diabetes Mellitus'. Healthcare, 9 (1):25-37 [DOI] [Details] |
|
| (2019) | 'Mineral Heterogeneity is Altered in the Femoral Heads of Osteoporotic and Diabetic Human Patients'
E. Parle, S. Tio, A. Behre, J. Carey, C. Murphy, T. O’Brien, W. Curtin, S. Kearns, J. McCabe, C.M. Coleman, T. Vaughan, L. McNamara (2019) 'Mineral Heterogeneity is Altered in the Femoral Heads of Osteoporotic and Diabetic Human Patients'. Journal of Bone and Mineral Research Plus, 4 (2):e10253-e10263 [DOI] [Details] |
|
| (2019) | 'Hypoxia Stimulates PTHrP and Zfp521 to Attenuate Hypertrophy in Mesenchymal Stem Cell Derived Cartilage'
D.C. Browe, C.M. Coleman, F.P. Barry, S.J. Elliman (2019) 'Hypoxia Stimulates PTHrP and Zfp521 to Attenuate Hypertrophy in Mesenchymal Stem Cell Derived Cartilage'. Scientific Reports, 9 (1):13274-13286 [DOI] [Details] |
|
| (2020) | 'Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery - a pilot study'
Galbraith AS;Sanz-Nogués C;Glynn S;Coleman CM;Murphy C; (2020) 'Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery - a pilot study'. Journal Of Orthopaedic Research, 38 (4):834-842 [DOI] [ARAN Link] [Details] |
|
| (2017) | 'Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction based detection of human DNA in murine organs'
Creane, M;Howard, L;O'Brien, T;Coleman, CM (2017) 'Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction based detection of human DNA in murine organs'. Cytotherapy, 19 :384-394 [DOI] [Details] |
|
| (2015) | 'Evaluation of Cartilage Repair by Mesenchymal Stem Cells Seeded on a PEOT/PBT Scaffold in an Osteochondral Defect'
Barron, V,Merghani, K,Shaw, G,Coleman, CM,Hayes, JS,Ansboro, S,Manian, A,O'Malley, G,Connolly, E,Nandakumar, A,van Blitterswijk, CA,Habibovic, P,Moroni, L,Shannon, F,Murphy, JM,Barry, F (2015) 'Evaluation of Cartilage Repair by Mesenchymal Stem Cells Seeded on a PEOT/PBT Scaffold in an Osteochondral Defect'. Annals Of Biomedical Engineering, 43 :2069-2082 [DOI] [ARAN Link] [Details] |
|
| (2015) | 'Pullulan: a new cytoadhesive for cell-mediated cartilage repair'
Bulman, SE,Coleman, CM,Murphy, JM,Medcalf, N,Ryan, AE,Barry, F (2015) 'Pullulan: a new cytoadhesive for cell-mediated cartilage repair'. Stem Cell Research & Therapy, 6 (34):1-12 [DOI] [Details] |
|
| (2014) | 'Chondrogenic Differentiation Increases Host Immune Response to Allogeneic Mesenchymal Stem Cell (MSC) Transplantation'
Ryan, A; Lohan, P; O'Flynn, L; Treacy, O; Chen, X; Coleman, CM; Shaw, G; Murphy, M; Barry, F; Griffin, M; Ritter, T (2014) 'Chondrogenic Differentiation Increases Host Immune Response to Allogeneic Mesenchymal Stem Cell (MSC) Transplantation'. Molecular Therapy, 22 (3):655-667 [DOI] [Details] |
|
| (2013) | 'Growth Differentiation Factor-5 Enhances In Vitro Mesenchymal Stromal Cell Chondrogenesis and Hypertrophy'
Coleman, CM,Vaughan, EE,Browe, DC,Mooney, E,Howard, L,Barry, F (2013) 'Growth Differentiation Factor-5 Enhances In Vitro Mesenchymal Stromal Cell Chondrogenesis and Hypertrophy'. Stem Cells And Development, 22 :1968-1976 [DOI] [Details] |
|
| (2012) | 'A role for MRP8 in in stent restenosis in diabetes'
Stocca, A; O'Toole, D; Hynes, N; Hynes, S; Mashayekhi, K; McGinley, L; Coleman, C.M; Sultan, S; Duffy, A; Tuney, T; O'Brien, T (2012) 'A role for MRP8 in in stent restenosis in diabetes'. Atherosclerosis, 221 (2):325-332 [DOI] [Details] |
|
| (2012) | 'Pre-treatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease'
Vaughan, E; Liew, A; Mashayekhi, K; Dockery, P; McDermott, J; Kealy, B; Flynn, A; Duffy, A; Coleman, C.M.; O'Regan A; Barry, F; O'Brien, T. (2012) 'Pre-treatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease'. Cell Transplantation, 21 (6):1095-1107 [DOI] [Details] |
|
| (2011) | 'Delayed Fracture Healing in Growth Differentiation Factor 5-deficient Mice: A Pilot Study'
Coleman, CM,Scheremeta, BH,Boyce, AT,Mauck, RL,Tuan, RS (2011) 'Delayed Fracture Healing in Growth Differentiation Factor 5-deficient Mice: A Pilot Study'. Clinical Orthopaedics And Related Research, 469 :2915-2924 [DOI] [Details] |
|
| (2003) | 'Growth/Differentiation Factor 5 Enhances Chondrocyte Maturation'
Coleman, C.M; Tuan, R.S. (2003) 'Growth/Differentiation Factor 5 Enhances Chondrocyte Maturation'. Developmental Dynamics, 228 (2):208-216 [DOI] [Details] |
|
| (2003) | 'Regulation of the Mouse Connexin-43 Promoter in Osteoblastic Cells and Embryos'
Chatterjee, B; Meyer, R; Loredo, G; Coleman, C.M; Tuan, R; Lo, C (2003) 'Regulation of the Mouse Connexin-43 Promoter in Osteoblastic Cells and Embryos'. Cell Adhesion and Communication, 10 (1):37-50 [DOI] [Details] |
|
| (2003) | 'Correlation of GDF5 and Connexin 43 mRNA Expression During Embryonic Development'
Coleman, C.M.; Loredo, G.A.; Lo, C.W.; Tuan, R (2003) 'Correlation of GDF5 and Connexin 43 mRNA Expression During Embryonic Development'. Anatomical Record, 275 (A):1117-1121 [DOI] [Details] |
|
| (2003) | 'Functional Role of Growth/Differentiation Factor 5 in Chondrogenesis of Limb Mesenchymal Cells'
Coleman, C.M.; Tuan, R (2003) 'Functional Role of Growth/Differentiation Factor 5 in Chondrogenesis of Limb Mesenchymal Cells'. Mechanisms Of Development, 120 (7):823-836 [DOI] [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2020) | 'The Role of Gender in the Onset, Development and Impact of Type 2 Diabetes and its Comorbidities'
F.C. Cassidy, S. Laffey, C.M. Coleman (2020) 'The Role of Gender in the Onset, Development and Impact of Type 2 Diabetes and its Comorbidities' In: Type 2 Diabetes. London: InTech Open. [Details] |
Reviews
| Year | Publication | |
|---|---|---|
| (2019) | Impact of Diabetes Mellitus on Bone Health.
C.E. Murray, C.M. Coleman (2019) Impact of Diabetes Mellitus on Bone Health. Reviews [DOI] [Details] |
|
| (2014) | Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?.
Lohan, P,Coleman, CM,Murphy, M,Griffin, MD,Ritter, T,Ryan, AE (2014) Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?. Reviews [DOI] [Details] |
|
| (2014) | From isolation to implantation: a concise review of mesenchymal stem cell therapy in bone fracture repair.
Watson L;Elliman SJ;Coleman CM; (2014) From isolation to implantation: a concise review of mesenchymal stem cell therapy in bone fracture repair. Reviews [DOI] [Details] |
|
| (2016) | Diabetic Bone Fracture Repair: A Progenitor Cell-Based Paradigm.
J. Hayes, C.M. Coleman (2016) Diabetic Bone Fracture Repair: A Progenitor Cell-Based Paradigm. Reviews [DOI] [Details] |
|
| (2013) | Enhancing the Mesenchymal Stem Cell Therapeutic Response: Cell Localization and Support for Cartilage Repair.
Bulman, SE,Barron, V,Coleman, CM,Barry, F (2013) Enhancing the Mesenchymal Stem Cell Therapeutic Response: Cell Localization and Support for Cartilage Repair. Reviews [DOI] [Details] |
|
| (2011) | Mesenchymal chondroprogenitor cell origin and therapeutic potential.
O'Sullivan, J,D'Arcy, S,Barry, FP,Murphy, JM,Coleman, CM (2011) Mesenchymal chondroprogenitor cell origin and therapeutic potential. Reviews [DOI] [Details] |
|
| (2010) | Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice?.
Coleman, CM;Curtin, C;Barry, FP;O'Flatharta, C;Murphy, JM (2010) Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice?. NEW ROCHELLE: MARY ANN LIEBERT, INC Reviews [DOI] [Details] |
|
| (2008) | Chicken Embryo as a Model for Regenerative Medicine.
Coleman, C.M; (2008) Chicken Embryo as a Model for Regenerative Medicine. Reviews [DOI] [Details] |
|
| (2003) | Morphogenesis and Dysmorphogenesis of the Appendicular Skeleton.
Shum, L; Coleman, C.M; Hatakeyama, Y; Tuan, R (2003) Morphogenesis and Dysmorphogenesis of the Appendicular Skeleton. Reviews [DOI] [Details] |
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2020 | Best New Postgraduate Programme | Grad Ireland | |
| 2018 | Invited speaker | European Orthopaedic Research Society | |
| 2017 | Invited speaker at Diabetes Ireland Conference & Exhibition | Diabetes Ireland | |
| 2016 | Invited speaker at Molecular Medicine Ireland | Molecular Medicine Ireland | |
| 2013 | Invited speaker at Trinity College Dublin | Trinity College Dublin | |
| 2011 | NCBES Post-Doctoral Research Award | NCBES Faculty | |
| 2010 | Cover Photograph | Human Gene Therapy | |
| 2010 | Best Abstract | International Cartilage Repair Society (Barcelona) |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| Orthopaedic Research Society | Member | 01-JAN-05 / 27-JUN-17 | |
| Irish Endocrine Society | member | 01-JUN-17 / 27-JUN-17 |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| CMNHS Graduate Research Committee | member | 01-AUG-18 / | |
| SNS Postgraduate Research Committee | member | 01-JAN-18 / 31-DEC-19 | |
| REMEDI Executive Management Committee | member | 01-NOV-16 / | |
| SoM Taught Post-Graduate Strategy Committee | member | 01-SEP-17 / |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| National Institutes of Health | Post Doctoral Fellow | 01-NOV-02 / 01-JAN-04 | |
| National University of Ireland Galway | Lecturer in Cellular Manufacturing and Therapy | 01-SEP-17 / | |
| National University of Ireland Galway | Senior Scientist in Orthobiologics | 10-JAN-07 / 30-SEP-13 | |
| Johnson & Johnson Regenerative Therapeutics | Senior Scientist in Cell Biology and Preclinical Evaluation | 01-JAN-04 / 01-DEC-06 | |
| National University of Ireland Galway | Research Fellow in Orthobiologics | 01-OCT-13 / 31-AUG-17 |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 2002 | Thomas Jefferson University | PhD | Developmental Biology and Teratology | |
| 2018 | National University of Ireland Galway | Postgraduate Certificate | Teaching and Learning in Higher Educaiton | |
| 1997 | Saint Michael's College | BSc | Biology, Minor in Chemistry |
Languages
| Language | |
|---|---|
| English |
Consultancy
| Client | Description | |
|---|---|---|
| Zoan Biomed |
Community Engagement
| Title | Type | From / To | |
|---|---|---|---|
| Outreach | Invited speaker at “Diabetes Ireland Conference & Exhibition" | / | |
| Outreach | Clinical Research Facility Galway open day guide and educator | / | |
| Outreach | Reel Life Science adjudicator | / | |
| Teaching (e.g. Service learning / comunity based learning) | Transition year student mentoring | / | |
| Outreach | Local judge in Debating Science Issues | / | |
| Outreach | National judge in Debating Science Issues | / | |
| Outreach | Invited speaker at “Diabetes: It’s Complicated” | / |
Reviews
| Journal | Role | |
|---|---|---|
| Scientific Reports | Reviewer | |
| Tissue Engineering | Reviewer | |
| Cells Tissues Organs | Reviewer | |
| Scientific Reports | Reviewer | |
| Journal Of Tissue Engineering And Regenerative Medicine | Reviewer | |
| Experimental Biology And Medicine | Reviewer | |
| Journal Of Orthopaedic Research | Reviewer | |
| Life Sciences | Reviewer | |
| Cell Transplantation | Reviewer | |
| Connective Tissue Research | Reviewer | |
| Irish Journal Of Medical Science | Reviewer | |
| Biomed Research International | Reviewer | |
| Regenerative Medicine | Reviewer | |
| Arthritis Research & Therapy | Reviewer | |
| Pnas | Reviewer | |
| Acta biochimica et biophysica Sinica | Reviewer | |
| Stem Cell Research & Therapy | Reviewer |
Other Activities
| Description | |
|---|---|
Review of grant proposals for: • Biotechnology & Bioresearch Sciences Research Council • Medical Research Council UK • Netherlands Organisation for Health Research and Development |
Teaching Interests
Recent Postgraduate Students
| Graduation | Name | Degree | Primary Supervisor | |
|---|---|---|---|---|
| 2013 | Sarah Flood | Msc | ||
| 2018 | Ti Zhang | Msc | ||
| 2018 | Anthony Sannicandro | Msc | ||
| 2019 | Cliodhna Murray | Msc | ||
| 2019 | Fiona O'Kelly | Msc | ||
| 2017 | Sophie Maybury | Msc | ||
| 2014 | Barry Murphy | Msc | ||
| 2018 | Clara Sanz Nogues | Msc | ||
| 2013 | Sarah Bulman | PhD | ||
| 2013 | Janice O¿Sullivan | PhD | ||
| 2011 | Rosanne Raftery | Msc | ||
| 2015 | Gillian Sexton | Msc | ||
| 2015 | Aine Fleming | Msc | ||
| 2012 | Sinead D¿Arcy | PhD | ||
| 2013 | Paul Loftus | Msc | ||
| 2012 | Dave McCarthy | Msc |
Modules Taught
| Term/Year | Module Title | Module Code | Subject / Desc | |
|---|---|---|---|---|
| 2019/20 | Cellular Manufacturing 1 | MD1524 | ||
| 2020/21 | Independent Study | MD1527 | ||
| 2019/20 | Mesenchymal Stromal Cell Therapy | MD1526 | ||
| 2019/20 | Cellular Manufacturing & Therapy Dissertation | MD1523 |
Internal Collaborators
| Name | Description of Collaboration | |
|---|---|---|
| Linda Howard | ||
| Sharon Glynn | ||
| Timothy O'Brien |
External Collaborators
| Name | Organisation / Institute | Country | Description of Collaboration | |
|---|---|---|---|---|
| Helen Burke | Galway University Hospitals | IRELAND | ||
| Colin Murphy | Galway University Hospitals | IRELAND | ||
| Declan Clarke | Zoan Biomed | IRELAND |
