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Medicine
Dr Ananya Gupta
Contact Details
Human Biology Building
NUI Galway
T: 091-492358
E: ananya.gupta@nuigalway.ie

Biography
Research Interests
Peer Reviewed Journals
Year | Publication | |
---|---|---|
(2018) | 'Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death'
Hossain MM;Barua D;Arabkari V;Islam N;Gupta A;Gupta S; (2018) 'Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death'. Oncotarget, 9 (14) [DOI] [Details] |
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(2020) | 'Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges'
Barua D;Gupta A;Gupta S; (2020) 'Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges'. Cancer Letters, 486 [DOI] [Details] |
|
(2020) | 'Differential expression, function and prognostic value of miR-17-92 cluster in ER-positive and triple-negative breast cancer'
Hossain MM;Sultana A;Barua D;Islam MN;Gupta A;Gupta S; (2020) 'Differential expression, function and prognostic value of miR-17-92 cluster in ER-positive and triple-negative breast cancer'. Cancer Treatment And Research Communications, 25 [DOI] [Details] |
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(2020) | 'XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation'
Barua D;Abbasi B;Gupta A;Gupta S; (2020) 'XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation'. Heliyon, 6 (10) [DOI] [Details] |
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(2016) | 'NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2 alpha-ATF4 signalling in breast cancer'
Gupta, A,Hossain, MM,Miller, N,Kerin, M,Callagy, G,Gupta, S (2016) 'NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2 alpha-ATF4 signalling in breast cancer'. Oncogene, 35 :5860-5871 [DOI] [Details] |
|
(2012) | 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'
Gupta, A,Caffrey, E,Callagy, G,Gupta, S (2012) 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'. Biochemical Society Transactions, 40 :752-758 [DOI] [Details] |
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(2011) | 'Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract'
Moran, AP,Gupta, A,Joshi, L (2011) 'Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract'. Gut, 60 :1412-1425 [DOI] [Details] |
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(2012) | 'Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis'
Gupta, S,Read, DE,Deepti, A,Cawley, K,Gupta, A,Oommen, D,Verfaillie, T,Matus, S,Smith, MA,Mott, JL,Agostinis, P,Hetz, C,Samali, A (2012) 'Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis'. Cell Death & Disease, 3 [DOI] [Details] |
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(2011) | 'Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract'
Moran, AP;Gupta, A;Joshi, L (2011) 'Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract'. Gut, 60 :1412-1425 [DOI] [Details] |
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(2012) | 'Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis'
Gupta S, Read DE, Deepti A, Cawley K, Gupta A, Oommen D, Verfaillie T, Matus S, Smith MA, Mott JL, Agostinis P, Hetz C, Samali A (2012) 'Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis'. Cell Death & Disease, 3 [DOI] [Details] |
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(2012) | 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'
Gupta, A;Caffrey, E;Callagy, G;Gupta, S (2012) 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'. Biochemical Society Transactions, 40 :752-758 [DOI] [Details] |
|
(2015) | 'Assays for Induction of the Unfolded Protein Response and Selective Activation of the Three Major Pathways'
Gupta, A;Read, DE;Gupta, S (2015) 'Assays for Induction of the Unfolded Protein Response and Selective Activation of the Three Major Pathways'. Methods in Molecular Biology, 1292 :19-38 [DOI] [Details] |
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(2016) | 'NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2¿-ATF4 signalling in breast cancer'
Gupta A;Hossain MM;Miller N;Kerin M;Callagy G;Gupta S; (2016) 'NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2¿-ATF4 signalling in breast cancer'. Oncogene, [DOI] [Details] |
|
(2016) | 'NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer'
Gupta A, Hossain MM, Miller N, Kerin M, Callagy G, Gupta S. (2016) 'NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer'. Oncogene, [Details] |
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(2016) | 'NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2 alpha-ATF4 signalling in breast cancer'
Gupta, A;Hossain, MM;Miller, N;Kerin, M;Callagy, G;Gupta, S (2016) 'NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2 alpha-ATF4 signalling in breast cancer'. Oncogene, 35 :5860-5871 [DOI] [Details] |
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(2011) | 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE'
Cawley, K;Deegan, S;Samali, A;Gupta, S (2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE'. Methods In Enzymology: Unfolded Protein Response And Cellular Stress, Vol 490, Pt B, 490 :31-51 [DOI] [Details] |
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(2018) | 'Hyperactivation of nuclear receptor coactivators induces PERK- dependent cell death'
Muhammad Mosaraf Hossain, David Barua, Vahid Arabkari, Md Nahidul Islam, Ananya Gupta and Sanjeev Gupta (2018) 'Hyperactivation of nuclear receptor coactivators induces PERK- dependent cell death'. Oncotarget, [Details] |
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(2016) | 'Reduced CREB3L2 expression is associated with resistance to sorafenib and poor prognosis in ER-positive breast cancer'
Sean Mullarkey, Vahid Arabkari, Muhammad Mosaraf Hossain,Sanjeev Gupta, Ananya Gupta (2016) 'Reduced CREB3L2 expression is associated with resistance to sorafenib and poor prognosis in ER-positive breast cancer'. [DOI] [Details] |
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(2015) | 'PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'
Gupta, A;Hossain, MM;Read, DE;Hetz, C;Samali, A;Gupta, S (2015) 'PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'. Scientific Reports, 5 [DOI] [Details] |
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(2017) | 'Glycosylation-Related Gene Expression in the Mucus-Secreting Gastrointestinal Cell Line HT29-MTX-E12 in Response to Infection by Helicobacter pylori'
Michael T Cairns; Ananya Gupta; Julie A Naughton; Marian Kane; Marguerite Clyne; Lokesh Joshi (2017) 'Glycosylation-Related Gene Expression in the Mucus-Secreting Gastrointestinal Cell Line HT29-MTX-E12 in Response to Infection by Helicobacter pylori'. Plos One, [Details] |
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(2016) | '1. IRE1-XBP1 regulates the expression of NCOA3 in breast cancer'
Ananya Gupta, Mosaraf Hossain, Mark Webber, Nicola Miller, Grace Callagy and Sanjeev Gupta (2016) '1. IRE1-XBP1 regulates the expression of NCOA3 in breast cancer'. Oncogene, [Details] |
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(2015) | 'PERK regulated miR-424-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'
Ananya Gupta, Mosaraf Hossain, Danielle Read, Mark Webber and Sanjeev Gupta. (2015) 'PERK regulated miR-424-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'. Scientific Reports, [DOI] [Details] |
|
(2012) | 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'
Gupta A, Caffrey E, Callagy G, Gupta S. (2012) 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'. [DOI] [Details] |
|
(2011) | 'Assays for detecting the unfolded protein response'
Cawley K, Deegan S, Samali A, Gupta S (2011) 'Assays for detecting the unfolded protein response'. Methods Enzymol, 490 :31-51 [DOI] [Details] |
|
(2011) | 'Assays for detecting the unfolded protein response'
Cawley K, Deegan S, Samali A, Gupta S. (2011) 'Assays for detecting the unfolded protein response'. Methods Enzymol, 490 :31-51 [Details] |
|
(2014) | 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'
Read, DE,Gupta, A,Ladilov, Y,Samali, A,Gupta, S (2014) 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'. Cell And Bioscience, 4 [DOI] [ARAN Link] [Details] |
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(2015) | 'PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'
Gupta, A,Hossain, MM,Read, DE,Hetz, C,Samali, A,Gupta, S (2015) 'PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'. Scientific Reports, 5 [DOI] [Details] |
|
(2014) | 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'
Read DE, Gupta A;Ladilov Y;Samali A;Gupta S (2014) 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'. Cell And Bioscience, 4 (1) [DOI] [Details] |
Book Chapters
Year | Publication | |
---|---|---|
(2015) | 'Assays for Induction of the Unfolded Protein Response and Selective Activation of the Three Major Pathways'
Gupta, A,Read, DE,Gupta, S,Oslowski, CM (2015) 'Assays for Induction of the Unfolded Protein Response and Selective Activation of the Three Major Pathways' In: Moethod and Protocols. UK: Elsevier Inc. [DOI] [Details] |
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(2015) | 'Assays for induction of the unfolded protein response and selective activation of the three major pathways'
Gupta A, Read DE, Gupta S (2015) 'Assays for induction of the unfolded protein response and selective activation of the three major pathways' In: Stress Responses - Methods and Protocols. Europe: Springer Link. [Details] |
Conference Publications
Year | Publication | |
---|---|---|
(2017) | San Antonio Breast Cancer Symposium; 2017 Dec 5-9
MM Hossain, V Arabkari, D Barua, A Gupta, MN Islam and S Gupta (2017) miR-17-92 cluster, an oncogenic microRNA cluster acts as a context dependent tumour suppressor in breast cancer. Cancer Res 2018;78(4 Suppl):Abstract nr P5-07-14 San Antonio Breast Cancer Symposium; 2017 Dec 5-9 [Details] |
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(2020) | American Association for Cancer Research. 2020
D Barua, A Sultana, MN Islam, A Gupta, S Gupta (2020) XBP1 regulates the expression of cell cycle associated genes in ERα positive breast cancer cells. Cancer Research 80 (16 Supplement), 5843-5843 American Association for Cancer Research. 2020 [Details] |
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(2017) | 15th CELT Symposium on Higher Education - Learning Communities, Collaboration, and Collegiality
Dempsey, M., Burns, D., Flynn, S., Gupta, A., Hogan, M., MacLochlainn, M., O’Connell, J., Ó Sealbhaigh, F. (2017) MISFITS: Lego, Wool, Art, Equations agus Seanfhocail 15th CELT Symposium on Higher Education - Learning Communities, Collaboration, and Collegiality [ARAN Link] [Details] |
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(2013) | Perk-dependent repression of miR-106b-25 cluster is required for ER stress induced apoptosis
Read, DE,Agostinis, P,Hetz, C,Mott, JL,Samali, A,Gupta, S (2013) Perk-dependent repression of miR-106b-25 cluster is required for ER stress induced apoptosis , pp.117-120 [Details] |
Other Journals
Year | Publication | |
---|---|---|
(2015) | 'Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis'
A Gupta, D Read, D Oommen, A Samali, S Gupta (2015) 'Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis' BioRxiv, . [Details] |
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(2016) | 'Reduced CREB3L2 expression is associated with resistance to sorafenib and poor prognosis in ER-positive breast cancer'
S Mullarkey, V Arabkari, MM Hossain, S Gupta, A Gupta (2016) 'Reduced CREB3L2 expression is associated with resistance to sorafenib and poor prognosis in ER-positive breast cancer' BioRxiv, . [Details] |
|
'Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis'
Ananya Gupta, Danielle Read, Deepu Oommen, Afshin Samali, SANJEEV GUPTA 'Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis' Biorxiv, . [DOI] [Details] |
Conference Contributions
Year | Publication | |
---|---|---|
(2013) | Edinburgh Pathology 2013, Joint Meeting with the BDIAP,
H Ingoldsby, E Caffrey, M Webber, D Wall, A Gupta, J Newell, S Gupta, G Callagy (2013) Characterisation of miR-4726 and miR-4728 in breast cancer. [Poster Presentation (Refereed)], Edinburgh Pathology 2013, Joint Meeting with the BDIAP, Edinburgh, UK , 18-JUN-13 - 21-JUN-13. [Details] |
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(2014) | IACR Annual Meeting,
A Gupta, G Callagy, S Gupta. (2014) Regulation of NCOA3/AIB1 expression by the unfolded protein response. [Poster Presentation], IACR Annual Meeting, Galway, Ireland , 27-MAR-14 - 28-MAR-14. [Details] |
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(2015) | IACR Annual Meeting,
A Gupta, MM Hossain, G Callagy, S Gupta (2015) XBP1 regulates the expression of NCOA3/AIB1 during unfolded protein response in breast cancer cells. [Poster Presentation], IACR Annual Meeting, Limerick, Ireland , 26-FEB-15 - 27-FEB-15. [Details] |
Abstract
Year | Publication | |
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(2010) | Co-ordinated regulation of gene expression by H-pylori in response to low pH and iron limiting growth conditions.
Moran, AP,Gupta, A,Ustinov, S,Mashayekhi, K (2010) Co-ordinated regulation of gene expression by H-pylori in response to low pH and iron limiting growth conditions. Abstract [Details] |
Editorial
Year | Publication | |
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(2018) | miR-17-92 cluster, an oncogenic microRNA cluster acts as a context dependent tumour suppressor in breast cancer.
Hossain, MM,Arabkari, V,Barua, D,Gupta, A,Islam, MN,Gupta, S (2018) miR-17-92 cluster, an oncogenic microRNA cluster acts as a context dependent tumour suppressor in breast cancer. Editorial [Details] |
Reviews
Year | Publication | |
---|---|---|
(2020) | Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges.
Barua, D;Gupta, A;Gupta, S (2020) Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges. CLARE: Reviews [DOI] [Details] |
Video recording / TV
Year | Publication | |
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(2017) | LSP for PD in Action.
Dempsey, M., Burns, D., Flynn, S., Gupta, A., Hogan, M., MacLochlainn, M., O’Connell, J., Ó Sealbhaigh, F. (2017) LSP for PD in Action. Mansion House, Dublin: Video recording / TV [Details] |
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(2017) | Professional Development Pilot: National Framework of Teaching and Learning in Higher Education.
Dempsey, M., Burns, D., Flynn, S., Gupta, A., Hogan, M., MacLochlainn, M., O’Connell, J., Ó Sealbhaigh, F. (2017) Professional Development Pilot: National Framework of Teaching and Learning in Higher Education. Video recording / TV [Details] |
Honours and Awards
Year | Title | Awarding Body | |
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2007 | Marie Curie Transfer of Knowledge Fellow | Marie Skłodowska Curie Foundation | |
1999 | Senior Research Fellowship | CSIR-UGC India | |
1997 | Junior Research Fellowship | CSIR-UGC India |
Professional Associations
Association | Function | From / To | |
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Physiology Society | full Member | / | |
Society of Cell Biologists, India | Member | / | |
European Association of Cancer Research | Member | / | |
American Association of Cancer Research | Member | / | |
Society for General Microbiology, Ireland | Member | / | |
Academy of Medical Laboratory Science | Full Member | / | |
Indian Biophysical Society, India | Member | / | |
Irish Association for Cancer research, Ireland | Member | / |
Committees
Committee | Function | From / To | |
---|---|---|---|
Graduate Research Council | Student Advisor | / |
Employment
Employer | Position | From / To | |
---|---|---|---|
NUI Galway | Lecturer (above the bar) | 07-JAN-16 / | |
NUI Galway | Postdoctoral researcher | 10-FEB-12 / 30-SEP-15 | |
NUI Galway | Postdoctoral researcher | 07-JUL-09 / 31-AUG-11 | |
NUI Galway | Marie Curie Transfer of Knowledge Research Fellow | 25-SEP-07 / 30-SEP-08 | |
University of Pennsylvania, Philadelphia, USA | Research Associate | 04-JAN-04 / | |
Orchid Pharmaceuticals Ltd. India | Senior scientist and Head of Cancer Drug Discovery | 01-JUN-06 / 01-AUG-07 |
Education
Year | Institution | Qualification | Subject | |
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1995 | Presidency College Calcutta India, Calcutta University | BSc (Hons) | Physiology | |
2016 | CELT, NUI Galway | Postgraduate Certificate in Higher Education Teaching | Teaching and Learning in Higher Education | |
1997 | Calcutta university | Msc | Biophysics and Molecular biology | |
2005 | Centre for Cellular and Molecular Biology, Jawaharlal Nehru University, India | PhD | Lifesciences - Immunology and host pathogen interactions |
Languages
Language | |
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English |
Community Engagement
Title | Type | From / To | |
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Outreach | Teen Tech | / | |
Outreach | Cell Exploreres | / |
Reviews
Journal | Role | |
---|---|---|
Journal Of Cellular And Molecular Medicine | Reviewer | |
Scientific Reports | Reviewer | |
Plos One | Reviewer | |
Journal Of Biological Chemistry | Reviewer | |
Apoptosis | Reviewer | |
Biochem Biophy Res Commun | Reviewer | |
Am J Physiol Cell Physiol | Reviewer |
Teaching Interests
Recent Postgraduate Students
Graduation | Name | Degree | Primary Supervisor | |
---|---|---|---|---|
2016 | Anhar Abdullah | Msc | Y | |
2013 | Louise Conlon | Msc | ||
2014 | Siobhan Kenny | Msc | ||
2015 | Alan O’Dwyer | Msc |
Modules Taught
Term/Year | Module Title | Module Code | Subject / Desc | |
---|---|---|---|---|
Biomedical Science 3rd Yer | Advanced Cardiovascular Physiology | SI326 | ||
Higher Diploma in Applied Science | Applied Microbiology and Immunology | AM1 | ||
Nursing Year 1 | Physiology | NU115 | ||
Biomedical Science BSc 4th Year | Case based Physiology | SI4101 | ||
MD Year 1 | Principles of Physiology | MD137 | ||
Biomedical Science BSc 2nd Year | Respiratory Physiology | SI212 | ||
Biomedical Science BSc 4th Year | Pathophysiology | SI432 | ||
MD Year 1 | Cardiovascular Physiology | MD121 | module coordinator | |
PG Diploma in Microbiology | Applied Microbiology and Immunology | PGM1 | ||
Biomedical Science BSc 2nd Year | Cardiovascular Physiology | SI208 | ||
Master of Cancer Biology | Molecular and cellular biology of cancer | GYT91 | ||
BSc Microbiology Year 3 | Immunology | MI317 | ||
Biomedical Science BSc 4th Year | Research Project | SI435 | ||
Nursing Year 3 | Physiology | NuU306 | ||
BSc Microbiology Year 3 | Immunology | MI330 | ||
Higher Diploma in Applied Science (Microbiology) | Analytical Microbiology and Quality Management Systems | MI504 | ||
Master of Science | Biotechnology | MT1 |