Biological and Chemical Sciences

Dr Eddie Myers

BA., MSc., PhD

Biography

2017 - Present: Lecturer in Organic Chemistry, NUI Galway
2014 - 2017: Research Officer, University of Bristol, Lab of V. Aggarwal
2012 - 2014: Associate Editor, Chemistry-A European Journal, Wiley-VCH
2012 - 2012: Assistant Editor, Angewandte Chemie, Wiley-VCH
2010 - 2012: LMU Research Fellow, LMU-Munich, Germany, Lab of D. Trauner
2006 - 2009: Postdoctoral Associate, University of Wisconsin–Madison, Lab of R. Raines
2002 - 2006: Ph.D., University of Bristol (2006), Lab. of V. Aggarwal
2002 - 2002: M.Sc. McGill University (2003), Lab of Y. Tsantrizos
1996 - 2000: B.A. Natural Science, Trinity College Dublin (2000), First Class, Gold Medal

Research Interests

Research in the Myers group lies at the interface between chemistry and biology. Current activities can be assigned to one or both of two themes: a) chemical biology of the extracellular matrix (ECM); b) novel methods for carbon-nitrogen bond formation.

Chemical Biology of the Extracellular Matrix (ECM)
Our goal is to elucidate in great detail the mechanism of formation of advanced glycation endproducts (AGEs), specifically crosslinks derived from ternary reactions of glucose, lysine and arginine. We are also interested in exploring the biological implications of our findings, particularly the role AGEs in diabetes, and potential avenues for therapeutic interventions. In the area of regenerative medicine, we are interested in developing small-molecule building blocks and reagents for generating collagen-and elastin-like materials with desirable mechanical and biochemical properties.

Novel Methods for Carbon-Nitrogen Bond Formation
We are interested in the design and development of main-group catalysts for the condensation of small-molecule carboxylic acids and amines. To support activities in our chemical biology theme, we are developing bioorthogonal reagents and methods for forming amide bonds involving large biomolecules. We are also exploring conceptually new ways of transforming azides.

Group Website: http://www.eddiemyerschemistry.com/

Peer Reviewed Journals

	Year	Publication
	(2017)	'The Story behind Synergy of Synthesis, Computation, and NMR Reveals Correct Baulamycin Structures' Lorenzo, Paula,Butts, Craig P.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'The Story behind Synergy of Synthesis, Computation, and NMR Reveals Correct Baulamycin Structures'. Biochemistry, [DOI] [Details]
	(2017)	'Stereodivergent Olefination of Enantioenriched Boronic Esters' Armstrong, Roly J.,Garcia-Ruiz, Cristina,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Stereodivergent Olefination of Enantioenriched Boronic Esters'. Angewandte Chemie - International Edition, 56 (3):786-790 [DOI] [Details]
	(2017)	'Selective uni- and bidirectional homologation of diborylmethane' Blair, Daniel J.,Tanini, Damiano,Bateman, Joseph M.,Scott, Helen K.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Selective uni- and bidirectional homologation of diborylmethane'. Chemical Science, 8 (4):2898-2903 [DOI] [Details]
	(2017)	'Iterative assembly line synthesis of polypropionates with full stereocontrol' Bootwicha, Teerawut,Feilner, Julian M.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Iterative assembly line synthesis of polypropionates with full stereocontrol'. Nature Chemistry, 9 (9):896-902 [DOI] [Details]
	(2017)	'Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes' Smith, James R.,Collins, Beatrice S. L.,Hesse, Matthew J.,Graham, Mark A.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes'. Journal Of The American Chemical Society, 139 (27):9148-9151 [DOI] [Details]
	(2017)	'Enantiospecific synthesis of ortho-substituted benzylic boronic esters by a 1,2-metalate rearrangement/1,3-borotropic shift sequence' Aichhorn, Stefan,Bigler, Raphael,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Enantiospecific synthesis of ortho-substituted benzylic boronic esters by a 1,2-metalate rearrangement/1,3-borotropic shift sequence'. Journal Of The American Chemical Society, 139 (28):9519-9522 [DOI] [Details]
	(2017)	'Photoinduced decarboxylative borylation of carboxylic acids' Fawcett, Alexander,Pradeilles, Johan,Wang, Yahui,Mutsuga, Tatsuya,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Photoinduced decarboxylative borylation of carboxylic acids'. Science (Washington, DC, United States), 357 (6348):283-286 [Details]
	(2017)	'Synergy of synthesis, computation and NMR reveals correct baulamycin structures' Wu, Jingjing,Lorenzo, Paula,Zhong, Siying,Ali, Muhammad,Butts, Craig P.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Synergy of synthesis, computation and NMR reveals correct baulamycin structures'. Nature, 547 (7664):436-440 [DOI] [Details]
	(2017)	'Asymmetric Synthesis of Secondary and Tertiary Boronic Esters' Collins, Beatrice S. L.,Wilson, Claire M.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Asymmetric Synthesis of Secondary and Tertiary Boronic Esters'. Angewandte Chemie - International Edition, 56 (39):11700-11733 [DOI] [Details]
	(2017)	'alpha-Sulfinyl Benzoates as Precursors to Li and Mg Carbenoids for the Stereoselective Iterative Homologation of Boronic Esters' Casoni, Giorgia,Kucukdisli, Murat,Fordham, James M.,Burns, Matthew,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'alpha-Sulfinyl Benzoates as Precursors to Li and Mg Carbenoids for the Stereoselective Iterative Homologation of Boronic Esters'. Journal Of The American Chemical Society, 139 (34):11877-11886 [DOI] [Details]
	(2016)	'Enantiospecific Alkynylation of Alkylboronic Esters' Wang, Yahui,Noble, Adam,Myers, Eddie L.,Aggarwal, Varinder K. (2016) 'Enantiospecific Alkynylation of Alkylboronic Esters'. Angewandte Chemie - International Edition, 55 (13):4270-4274 [DOI] [Details]
	(2016)	'Regio- and Stereoselective Homologation of 1,2-Bis(Boronic Esters): Stereocontrolled Synthesis of 1,3-Diols and Sch 725674' Fawcett, Alexander,Nitsch, Dominik,Ali, Muhammad,Bateman, Joseph M.,Myers, Eddie L.,Aggarwal, Varinder K. (2016) 'Regio- and Stereoselective Homologation of 1,2-Bis(Boronic Esters): Stereocontrolled Synthesis of 1,3-Diols and Sch 725674'. Angewandte Chemie - International Edition, 55 (47):14663-14667 [DOI] [Details]
	(2016)	'Synthesis of 3-Aryl-1-aminopropane Derivatives: Lithiation-Borylation-Ring-Opening of Azetidinium Ions' Casoni, Giorgia,Myers, Eddie L.,Aggarwal, Varinder K. (2016) 'Synthesis of 3-Aryl-1-aminopropane Derivatives: Lithiation-Borylation-Ring-Opening of Azetidinium Ions'. Synthesis, 48 (19):3241-3253 [DOI] [Details]
	(2014)	'Total Synthesis of the Proposed Structure of Trichodermatide A' Myers, Eddie,Herrero-Gomez, Elena,Albrecht, Irina,Lachs, Jennifer,Mayer, Peter,Hanni, Matti,Ochsenfeld, Christian,Trauner, Dirk. (2014) 'Total Synthesis of the Proposed Structure of Trichodermatide A'. Journal Of Organic Chemistry, 79 (20):9812-9817 [DOI] [Details]
	(2009)	'A phosphine-mediated conversion of azides into diazo compounds' Myers, Eddie L.,Raines, Ronald T. (2009) 'A phosphine-mediated conversion of azides into diazo compounds'. Angewandte Chemie - International Edition, 48 (13):2359-2363 [DOI] [Details]
	(2007)	'Chalcogenides as Organocatalysts' McGarrigle, Eoghan M.,Myers, Eddie L.,Illa, Ona,Shaw, Michael A.,Riches, Samantha L.,Aggarwal, Varinder K. (2007) 'Chalcogenides as Organocatalysts'. Chemical Reviews, 107 (12):5841-5883 [DOI] [Details]
	(2007)	'A new manifold for the Morita reaction: Diene synthesis from simple aldehydes and acrylates/acrylonitrile mediated by phosphines' Palmelund, Anders,Myers, Eddie L.,Tai, Lik Ren,Tisserand, Steve,Butts, Craig P.,Aggarwal, Varinder K. (2007) 'A new manifold for the Morita reaction: Diene synthesis from simple aldehydes and acrylates/acrylonitrile mediated by phosphines'. Chemical Communications, (40):4128-4130 [DOI] [Details]
	(2007)	'Reactions of iminium ions with Michael acceptors through a Morita-Baylis-Hillman-type reaction: enantiocontrol and applications in synthesis' Myers, Eddie L.,de Vries, Johannes G.,Aggarwal, Varinder K. (2007) 'Reactions of iminium ions with Michael acceptors through a Morita-Baylis-Hillman-type reaction: enantiocontrol and applications in synthesis'. Angewandte Chemie-International Edition, 46 (11):1893-1896 [DOI] [Details]
	(2006)	'BF3·OEt2 and TMSOTf: A synergistic combination of Lewis acids' Myers, Eddie L.,Butts, Craig P.,Aggarwal, Varinder K. (2006) 'BF3·OEt2 and TMSOTf: A synergistic combination of Lewis acids'. Chemical Communications, (42):4434-4436 [DOI] [Details]
	(2004)	'Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties' Fader, Lee D.,Myers, Eddie L.,Tsantrizos, Youla S. (2004) 'Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties'. Tetrahedron, 60 (10):2235-2246 [DOI] [Details]

Book Chapters

	Year	Publication
	(2012)	'Selected diastereoselective reactions: electrocyclizations' Myers, E. L.,Trauner, D. (2012) 'Selected diastereoselective reactions: electrocyclizations' In: Compr. Chirality. :563-606 Amsterdam: Elsevier B.V. [Details]

Honours and Awards

Year	Title	Awarding Body
2009	Alexander von Humboldt Fellowship (declined)	Alexander von Humboldt Foundation
2009	LMU Research Fellowship	LMU-Munich
2003	Dean's Honor List	McGill University
2002	T. Sterry Hunt Award for Excellence in Teaching	McGill University
2001	Alexander McFee Fellowship	McGill University
2000	Graduate Award	Institute of Chemistry of Ireland
2000	Cocker Prize and Medal	Trinity College Dublin
2000	John Winthorp Hackett Moderatorship Prize	Trinity College Dublin
2000	Gold Medal	Trinity College Dublin
1999	Dr. George A. Lonergan Prize	Trinity College Dublin
1998	Elected Scholar of Trinity College	Trinity College Dublin
1998	D.C. Pepper Prize	Trinity College Dublin
1997	Eli Lilly Chemistry Prize	Trinity College Dublin
1997	Henley Memorial Prize	Trinity College Dublin

Employment

Employer	Position	From / To
University of Bristol	Research Officer	01-OCT-14 / 31-AUG-17
Wiley-VCH	Associate Editor	01-SEP-12 / 30-SEP-14
Wiley-VCH	Assistant Editor	01-FEB-12 / 31-AUG-12
LMU Munich	LMU Fellow	15-DEC-09 / 31-DEC-11
University of Wisconsin-Madison	Postdoctoral Associate	01-OCT-06 / 30-NOV-09

Education

Year	Institution	Qualification	Subject
2006	University of Bristol	PhD	Organic Chemistry
2003	McGill University	MASTERS OF SCIENCE	Organic Chemistry
2000	Trinity College Dublin	Bachelor of Arts	Natural Science/Chemistry

Modules Taught

	Term/Year	Module Title	Module Code	Subject / Desc
	Semester II/2024	Computers and Chemical Research	CH3101	Technical Writing and Report Writing
	Semester II/2024	Organic Chemistry	CH4113	Pericyclic and Radical Reactions