Applications are invited for a fully funded PhD research position commencing between June and August 2025.  The post is part of a larger comprehensive project that involves investigating and developing the use of novel 4 and 5-dimensional fluorescence measurement methods for the quantitative analysis of macromolecules in complex environments, particularly for Downstream Processing (DSP).  The research straddles both fundamental and applied research domains and builds on our recent investigations which showed that polarized Excitation Emission Matrix (pEEM) measurements which is combination of scatter and polarized emission, provides a unique methodology for monitoring simultaneously both physical and chemical changes in therapeutic proteins. These positions are part of the Downstream Protein Analysis - Polarized Emission Spectroscopy (DPA-PES), project funded by Science Foundation Ireland (grant 22/FFP-A/10271). 

NBL-P3:  Antibody Drug Conjugate (ADC) analysis by Polarized Excitation Emission Matrix (pEEM) spectroscopy:  ADC’s are an important class of bio-pharmaceuticals with potentially huge benefits for the treatment of diseases like cancer.  Some of the challenges facing the manufacture and thus adoption of these novel medicines are the need to accurately monitor their synthesis, analyse product variance, and to characterize the complex final drug product.  Variations in drug to antibody ratio (DAR) and labeling position affects physicochemical and aggregation behaviour which in turns impacts on drug efficacy in‐vivo.  Thus measuring with a high degree of precision both the drug binding position and numbers of conjugated moieties is critical, to enable lower-cost, more effective manufacturing.  In this project we want to investigate the use of pEEM for monitoring the kinetics of ADC synthesis reactions and the quantitative analysis of DAR and aggregation of the final products and formulations.

References:  See www.universityofgalway.ie/nanoscale/publications/ for more details about pEEM. 

Academic Entry Requirements:

A first or upper second class honours undergraduate degree (or equivalent) in Physical Sciences (Chemistry, Physics, or Biochemistry), or have completed an M.Sc. degree in (Bio)Analytical Chemistry or Biophysics.  Previous relevant research or industry experience is particularly valuable.  Non-native English speakers must satisfy the University of Galway English Language Entry Requirements available here.  IELTS score of >6.5 or TOEFL IBT scores of >92.

Experience in the following techniques would be very beneficial:  Dynamic Light Scattering, HPLC, Fluorescence spectroscopy, protein purification & analysis, multivariate data analysis.

Living allowance (Stipend): €22,000 per annum, tax-exempt scholarship award.

University fees:  Four years EU fees are funded.  A student levy applies (currently €140 per annum).  Exceptional non-EU students can avail of a PhD International Merit Scholarship to waiver the non-EU fee component.

Start date:  01/June/2025 (or as soon as possible thereafter).

To Apply for the Scholarship: 
Expressions of interest comprising submission of:

• A covering letter (outlining interests, and motivation for pursuing a PhD), max 1-page,
• A detailed CV (2-5 pages) describing your academic and research (or industry) experience,
• Evidence for proficiency in the English Language (e.g. TOFL scores/certificate):  
• A pdf copy of your degree transcripts, and
• Names and contact details for three referees willing to provide a confidential reference.

to be submitted as a single pdf file via e-mail to the contact below.  Please indicate your choice of projects in order of preference.

Contact Name:  Prof. Alan G. Ryder  Contact Email:  alan.ryder@universityofgalway.ie

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In addition to the specific funded positions we also have opportunities for research in several other areas of fluorescence and Raman spectroscopy.  Funding for this research is available from both the Irish Research Council postgraduate scholarship scheme and from the Hardiman PhD Scholarships offered by the University of Galway. These are awarded by open competition.   These awards provides a maintenance award of up to  €22,000, pays fees, and some travel/training expenses.  The awards are open to all EU citizens and very exceptional candidates from outside the EU. 

The Hardiman call for 2026 will open later this year(check the website).

The 2026 GOIPG will open in Sept. 2025.  Details are available HERE.

Interested candidates should have at least a 2:1 degree in chemistry or physics (or another relevant science or engineering degree), or preferably have an M.Sc. qualification.  English language proficiency is a requirement. 

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Other Postdoctoral Positions: 

We welcome applications for the Irish Research Council GOIPD  postdoctoral fellowship programme.
The next (2026) GOIPD call will open in Sept. 2025.  Details are available HERE.

We are also always interested in Marie Curie Incoming Fellowship applications from suitably qualified candidates in the areas of biophysics, fluorescence spectroscopy, chemometrics, instrumentation, and process analytical technologies. The call will have a deadline in Oct. 2025.

Much of our research involves fluorescence EEM and multi-way chemometric methods for the analysis of proteins, cell culture media,  and other complex biogenic samples from bio-pharmaceutical manufacturing processes.  We are always interested in potential candidates who are proficient in the following:  Biophysics, Optical Instrumentation, Multi-way chemometrics ), analytical chemistry, fluorescence spectroscopy (specifically EEM), and analytical method development, and scientific.  Other desirable skills include:  practical experience of protein analysis, industrial bio-analysis.

We are particularly interested in candidates with experience of building spectroscopic instrumentation

Interested candidates should send a detailed CV with the names of at least three referees. E-mail: alan.rydernuigalway.ie
Please include details of relevant research and/or work experience and a list of publications.

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Undergraduate Research Internships.

We will also from time to time host visiting undergraduate researchers under EU (e.g. Erasmus+) or other programmes.  Interested parties should get in contact by email. 
The Royal Society of Chemistry operate an Analytical Chemistry Summer Studentships funding scheme.  The deadline is normally in January every year.  This is ideal for third year UoG physics or chemistry undergraduate students and will cover a stipend for 8 weeks research in a laboratory.   This is a competitive application process. 

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Useful Links

• Physics at Galway:  www.universityofgalway.ie/physics/
• Postgraduate prospectus & information about NUI-Galway:   www.universityofgalway.ie/choose-postgrad/prospectus/   This contains a lot of useful information about studying at the University of Galway.
• Visit Galway.
• University Vacancies Ireland. 

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